Protein Details: Aquaporin TIP1-2

Protein ID

ICDB_Pro_0942

Protein Name

Aquaporin TIP1-2

Gene Name

TIP1-2; SITIP; TIP2; At3g26520; MFE16.17

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

253 amino acids

AlphaFoldDB

AF-Q41963-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition. Transports urea in yeast cells in a pH-independent manner. Transports H(2)O(2) in yeast cells.

Sequence

MPTRNIAIGGVQEEVYHPNALRAALAEFISTLIFVFAGSGSGIAFNKITDNGATTPSGLVAAALAHAFGLFVAVSVGANISGGHVNPAVTFGVLLGGNITLLRGILYWIAQLLGSVAACFLLSFATGGEPIPAFGLSAGVGSLNALVFEIVMTFGLVYTVYATAVDPKNGSLGTIAPIAIGFIVGANILAGGAFSGASMNPAVAFGPAVVSWTWTNHWVYWAGPLIGGGLAGIIYDFVFIDENAHEQLPTTDY

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Predominantly expressed in roots.

DOI ID

10.1093/dnares/7.2.131; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1046/j.1365-313x.1993.04061051.x; 10.1186/gb-2001-3-1-research0001; 10.1104/pp.103.027409; 10.1099/vir.0.82252-0; 10.1074/jbc.m603761200

RefSeq

NP_189283.1